The AI Institute for Next Generation Food Systems (AIFS) aims to meet growing demands in our food supply by increasing efficiencies using AI and bioinformatics spanning the entire system — from growing crops through consumption. AIFS tackles three key challenges in its implementation by integrating digital and biological technologies to provide solutions that address the complexity and diversity of food systems, developing models and obtaining data sets for AI that are publicly available, and improving the safety, efficiency, and accuracy of food system tasks that requires human involvement and decision-making.